Viral vector delivery of Env trimer immunogens
نویسندگان
چکیده
منابع مشابه
Structure and Dynamics of the Native HIV-1 Env Trimer.
HIV-1/AIDS remains one of the worst pandemics in human history. Despite tremendous efforts, no effective vaccine has been found. Recent reports give new insights into the structure and dynamics of the HIV-1 Env trimer and renew hopes that a better understanding of Env will translate into new vaccine candidates and more-effective antiretroviral therapies.
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Plant systems for the production of recombinant immunogens have the potential to overcome obstacles currently impeding the delivery of vaccines to poorer, more remote populations by localizing production and reducing associated costs. The nature of the future plant-derived vaccine candidates will have an important impact on the extent to which universal access to vaccines can be achieved using ...
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Integrating viral gene delivery with engineered biomaterials is a promising strategy to overcome a number of challenges associated with virus-mediated gene delivery, including inefficient delivery to specific cell types, limited tropism, spread of vectors to distant sites, and immune responses. Viral vectors can be combined with biomaterials either through encapsulation within the material or i...
متن کاملSaturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations
The conformation of HIV-1 envelope (Env) glycoprotein trimers is key in ensuring protection against waves of neutralizing antibodies generated during infection, while maintaining sufficient exposure of the CD4 binding site (CD4bs) for viral entry. The CD4 binding loop on Env is an early contact site for CD4 while penetration of a proximal cavity by CD4 triggers Env conformational changes for en...
متن کاملSelected HIV-1 Env Trimeric Formulations Act as Potent Immunogens in a Rabbit Vaccination Model
BACKGROUND Ten to 30% of HIV-1 infected subjects develop broadly neutralizing antibodies (bNAbs) during chronic infection. We hypothesized that immunizing rabbits with viral envelope glycoproteins (Envs) from these patients may induce bNAbs, when formulated as a trimeric protein and in the presence of an adjuvant. METHODS Based on in vitro neutralizing activity in serum, patients with bNAbs w...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2012
ISSN: 1742-4690
DOI: 10.1186/1742-4690-9-s2-p341